I'm currently at Flight Express. Decent pay flying C210 and Baron. It's a dead end for the long term though, so I'm looking for something else at the moment. This was more of a "get a foot in the part 135 world" with my low multi-time. At the moment I'm thinking of sticking with cargo at the moment. Given my past two jobs, I can't stomach the thought of making a 1/3rd of what I've made in the past by going to a regional. I'd throw out the notion of going straight to a major. That was kind of my original strategy. Find a place that had metros or 1900s, get a bunch of TPIC and skip the regional drama. That doesn't seem very common anymore. From what I can tell, they want Jet/Glass/multi-crew. The jet and multi-crew I can KIND OF see, but that's seems more of a learning/personality issue rather than an experience one. The glass requirement seems like non-sense, that's easier! Whatever, that's what they want, can't get worked up about it.
From talking to various Ameriflighters while sitting around the FBO, most seem to be jumping ship to the 121 regional world. These guys are in the 99s and 3 are eligible to move to the metro. Seems silly to go to the regionals at that point as they're on the verge of flying the monster and being pretty marketable for those cush air ambulance/corporate jobs.
Bottom line, think about where you want to go long term. If 121 major is your goal, regionals are probably your best choice, and if that's where you want to go, seniority is everything. So go there NOW. Like yesterday! heheh If corporate/135 is your goal, do cargo. It comes down to networking mainly. Cargo guys have a hard time networking with the 121 world and vice-versa. I still don't know, so I'm going to go where the money is.
Think about this too, the more money you save in your 20s, the better off you are later on even if you don't get to that 150k+/year job. The guy that goes the regional route and makes it to that 150k/year job at a major will still make less money in their career than a cargo guy that went corporate. I know, money isn't everything, but I know far too many people that are enamored by that pay scale on airlinepilotcentral, blocking out all the other opportunities in aviation that pay A LOT more starting out. Just something else to consider.