Well, let's look at that a little more closely.
I don't believe it's ever fair to say a pilot's experience level was the direct cause of an accident. For example, it would be a stretch to say "that plane crashed BECAUSE the pilot only had 100 hours", because that's the same as saying that no aircraft flown by a pilot with 100 hours has ever NOT crashed--which we know is false. Of course, experience level does factor into the question of whether a pilot could've prevented an accident--either by act of commission or omission. Thus, experience level can be a contributing factor in any accident.
Now, relatively speaking, regional pilots ARE inexperienced, compared to their mainline brethren. Remember that the pilots of the US Airways flight had nearly 40,000 hrs between the two of them; the Colgan pilots had something like 1/8th as much experience between them. We'll just never know whether a captain of Doug's experience level rather than one of FlyChicaga's would've been able to prevent Thursday's tragedy, but I've long thought that the left seat of an RJ should be where you go after you've worked your way up to widebody FO at a mainline carrier, not after you've been an RJ FO for a couple three years. Yes, I know the standards are the same whether you've got 1500 hours or 15,000, but the skill levels just aren't comparable.
Do I think this difference will be highlighted in the inevitable wrongful death trials? Absolutely. I guarantee some trial lawyer will ask a jury to ponder this question: "Continental Airlines is selling the experience level of a Continental Airlines crew to its customers, yet delivering that of a Colgan crew without the customer's knowledge or consent; therefore, isn't the risk imposed by this substitution entirely Continental's?"