From a safety standpoint, the training depatrments should take care of this. You simply need to make training thorough and difficult enough to weed out pilots who can't hack it, wether they be 10,000 hour or 500 hour pilots.
Yes, I was hired into the right seat an RJ with less than 1000 hours and no prior turbine experience, but I didn't attend a "pilot factory". There were 4 or 5 of us with under 1000TT in my newhire class of 31. The lowest time pilot, who had about 500 hrs, didn't make it through IOE. The training was good, therefore I felt competent during IOE and my first few months on the line, yet I was aware of my inexperience and solicited as much advice as I could from the captains I flew with. Yeah, I made some mistakes and I'm sure the captains weren't thrilled with having to hold my hand through routine stuff at first, but hey, you get what you pay for. Guess what the regoinals are paying for right now with $20/hr FO wages? Sub-1000hr pilots.
From a standpoint of "what's good for the profession", RJ's, or even regional flying at any level probably should never have been taken away from mainline and outsourced to B-scale pilot groups like my own. If that were the case, you'd still need a college degree, at least a few thousand PIC, and an ATP before you ever got into the right seat of a jet. However, I can't blame low time pilots for taking these jobs as as soon as they meet the mins. Seniority means so much, and I just can't see someone passing up a regional job to "build character" instructing while their couterparts are accruing seniority while making just as much, if not more money in most cases.
Even with the mins at 400 hours, it will still be necessary for the average pilot to instruct before they can qualify, even if they just do it for just a few months. And keep in mind this is eagle we're talking about....very few people will touch that place for fear of an 8 year+ upgrade or possibly being furloughed if something happens at American.