1. Flow Through agreements are ALPA fraud. You will be prevented from progressing at your carrier of choice if you fly for a wholly owned regional. They can and do prevent pilots from receiving calls for interviews. They cancel interviews. They rescind job offers. They will poach the competition's labor instead.
2. Never ask your union, your company, or your AME for help with transient depression, or anything that could ground you. Never disclose anything to the FAA that you don't have to. Life gets tough on fast food wages and a regional can easily become a trap if you are vocal about union issues. Its better to vote with your feet, if you can.
3. The simulator is often used as a tool of discipline. Most company's have a simulator instructor drunk on ego. Find out who they are and never agree to a training cycle with one. Call in sick.
4. Don't drink too much and, if you are ever in a position where its show time and you are hungover, call in sick, resign, and do NOT fly. Do not enter HIMS.
5. Don't fly fatigued.
6. Congratulations! You made it.