Triple redundant hydraulics, at least dual redundant power plants, triple redundant electrics, single point of failure in the cockpit.
Nope. Never gonna happen. Not as long as there exists a pilot union and a flying population that's not suicidal.
Get rid of the F/O or relief pilots? Who will heat up the Captain's food? It is a terrible idea...unless FedEx and UPS can get some smoking hot galley wenches.I can see this at FedEx or UPS long before an airline. As soon as they do it safely for a year or two I am sure the airlines will try it.