What to do in San Diego?
I know it's touristy and all that, but the Zoo is really cool. I was born in San Diego and I still like going there. Be prepared to wait in a long line if you want to go see the pandas. It is worth the wait, although you'll probably see them being total slackers and sleeping or being pigs and chowing down on bamboo. You can kill an entire day just strolling through the Zoo. If you decide to leave the Zoo early, it's right in Balboa Park, so you can wander through there. Check out the organ and the museums.
If you want to stick with the animal theme, there's the Wild Animal Park. That's where they put the animals they can't put in the zoo and while I've never gone on that tour, I've heard good things about it.
Since you're going with your wife, you definitely want to wander through La Jolla. She will want to browse the shops so make sure you put your credit card away. Grab a beer at Moondoggie's if you're in the mood to meet some cool people. Walk down to the park and wander on down to the beach. If you're in the mood for a quick bite to eat, head up to George's but make sure you go upstairs. The view is so much better there. If you like sushi like I do, head over the the Hyatt and check out Cafe Japengo.
If you feel like going out, head down to the Gaslamp. There are so many places you can wander into for a drink that it's insane. You will run into a lot of tourists but a lot of locals go there as well. My favorite place there is Onyx.
And a really cool place to go for dinner is Anthony's. It's right on the harbor, right next to the airport. You can pick the one you want to go to. There's one that's just kind of like a typical restaurant, and then there is the Star of the Sea, which has great food and great service, but you will pay for it.
I think that will keep you busy for the weekend. If you're looking for more to do, go to
www.signonsandiego.com and check out the visitor's guide.