Yep. My medication, passport, pilot certificate, etc. is in my computer case that comes with me. Everything else is easily replaceable and doesn't need to be a foot from my side at every second of the flight.
I came to the conclusion a while ago that travel really isn't all that bad. It's the people that you're stuck flying with that are what can make it miserable. Whether it's the toddler whose incompetent parents let him run up and down the aisle hitting all of the seats, or the • trying to cram a monstrous bag into an overhead bin, or the guy on his cell phone talking at 300 decibels just so you know how important he is, the fact of the matter is that it's not the airlines that make travel miserable; it's the people. And it just gets worse if you're flying on a certain airline whose people think it's just gosh golly wonderful to rap a boarding announcement over the PA or play a "cabin game" in flight while you're trying to sleep or get some work done.