Inverted
mmmmmm wine
Timing would be a issue. What makes feeder fright works is that it's timed sometimes to the minute on departing and arriving to optimize when the freight leaves the facility, loaded onto the plane, and flown to the plane. Sure one big plane can make multiple stops and carry lots of cargo. But can it do that and still make it to the facility on time, be of loaded, and loaded onto the big jet. There were some stops on some runs at AMF that you had to turn the plane in less than 15 minutes or you'd be late. I don't see a CRJ turning that quickly.
I also don't see a CRJ filling the mission of making 2-3 stops, unloading 200 lbs of cargo then shoving off to the next leg.