VFR - Yes, but it depens on intrepretation. 91.103 and specifically, 91.503: "(a) The pilot in command of an airplane shall ensure that the following flying equipment and aeronautical charts and data, in current and appropriate form, are accessible for each flight at the pilot station of the airplane: (3) Pertinent aeronautical charts." The interpretation comes in to what exactly does "pertinent" mean?
IFR - Yes. 91.503: "(a) The pilot in command of an airplane shall ensure that the following flying equipment and aeronautical charts and data, in current and appropriate form, are accessible for each flight at the pilot station of the airplane: (4) For IFR, VFR over-the-top, or night operations, each pertinent navigational en route, terminal area, and approach and letdown chart. "