DE727,
Remember, all we fly is freight. If we carried pax, then it would be harder, but I know a few companies who do pax in Meridians, Pilatus', etc. Freight can be single engine all it wants. There are 135 companies in AK that operate C-172's for freight.
We use caravans, and a lot of companies start their new people in single engine airplanes, then upgrade into twins (Package Express, Ram Air Freight, Flight Express, to name a few).