I think the 2 big elephants in the room are the Feds and Insurance.
The regulations are going to be so slow to catch up to the technology the conversation is almost moot for anyone flying professionally today. The funding for evaluations after testing after evaluation after testing is going to be tied up in congress for years to come. To think this is going to be approved quickly for 121/135 ops is laughable.
Why are LPV approaches considered precision approaches for training and checkrides but not for actual flight planning? Yeah, no ape airplane regulations are going to be fun to watch come out.
Having just watched my current shop go through an insurance adjustment for the next few years their requirements are tightening and tightening causing more cost to the company to be in compliance so that there is coverage. Good luck getting any one of those companies to sign up to cover the first 50 of these airplanes to come out. And even if you do, say the worst happens and one plows into a playground during recess, who's covering it? The company that operates the airplane? The manufacture that said the airplane was safe and sound? The company that built the individual component that failed and caused the crash? Which insurance company is going to cover the liability? Once you take the apes out of the loop the blame is going to have to shift somewhere.