It definitely look like you've put some thought and research into this. However, you are (probably unwittingly) contradicting yourself here:
So Regional looks like the best short term place to meet long term goals.
That said. I ranked the top 10 Regionals by order of choice as follows for my situation:
1. SkyWest
2. Express Jet
3. PSA
4. Compass
5. Air Wisconsin
6. American Eagle
7. Go Jet
8. Pinnacle
9. TSA
10. Republic
Your top five choices are all excellent, but they are long term choices. As of now (which is rapidly changing) your top five all have a 5-10 year upgrade time, so it's going to take you a while to get that twin turbine PIC that you want. Also, you mentioned QOL, and I am assuming that you structured your list with this in mind. The nature of the beast is that you aren't going to find QOL and a quick upgrade time at the same company. Obviously, if people are happy where they are (good QOL) they aren't as likely to leave, so the upgrade time will be higher. Based on my (admittedly minimal 3.5 years) experience in the industry I would recommend rethinking your list with this in mind:
You mentioned in a later post that making a career at a regional may be an option. If so, keep looking at the choices you are looking at. However, if you are looking to round out your resume/logbook with PIC twin turbine as quickly as possible then you may want to rethink things a little. Some of your lower choices are going to offer a much quicker upgrade, so you need to balance that against your financial/QOL needs, because you are not going to get both. (A caveat, if you are looking to fast track to a major, some guys have been hired out of the right seat of a jet. It's rare, and in my opinion, somewhat unfair to
some of the captain applicants with command experience, but that's a different discussion.)
Being home based is a QOL gamechanger. If you happen to live in base for ANY carrier, your QOL will be better than commuting to the best carrier on your list. If you are willing to move, then you can do a straight up comparison, but from what you are saying, it sounds like you may be tied down to either San Antonio or Dayton. San Antonio I can't help you with, but I can help with Dayton.
Assuming living in DAY:
I did some quick research on APC, and it looks like PSA has a DAY base (I had no clue). That would move PSA to the top of the list for me. My only concern would be that PSA's future is uncertain given the Airways/American merger (same goes for Air Whisky and Eagle). I don't think they are going away, but they may get stepped on with some sort of concessionary contract. They may also turn out great, but it's hard to know.
Normally, I'd not only agree with you about Republic, but I'd tell you to stay away. I've heard enough mixed reviews that it sounds like commuting to reserve for them would REALLY suck. However, all of their subsidiaries have bases in CMH, which will be an easy driving commute for you. With them, I'd just make absolutely sure that you know the equipment and base you are being hired into before you commit.
ExpressJet would be a great third choice, and they have bases all over, and their work rules should make them easy to commute to. With DAY in mind, CLE should be an easy drive/fly commute, and ORD would be a good second choice. After those three, your pick is as good as mine. I would definitely avoid anything that's going to force you into a 2 leg commute (passrider.com is good for research). SkyWest is more focused out west, so San Antonio may bring them into play.
Ok, that book over, I'm going to do a little advertising for a carrier not on your list. Assuming living in Dayton, have you looked at CommutAir at all? We have better work rules than Republic (Cancellation pay, leg by leg block or better, better reserve rules), and roughly equivalent pay scales*, but our upgrade time is 18-24 months. We have a number of guys that commute from Dayton to CLE using a mix of driving and flying, and I've heard no complaints. It's a small company with very much a family atmosphere, and the union has a good working relationship with management (huge difference from Republic). The company is very stable, run in a conservative fashion, and the Dash 8 is so cheap to operate that I don't see any of our flying going anywhere soon. So, again, it depends on what you want, but if your primary goal is to round out your resume/logbook quickly and move on, I'd definitely take a good look at CommutAir.
*First year FO pay is the same. A second year FO at Republic will make more, but a second year FO a CommutAir will most likely upgrade sometime in his or her second year, and will be making Captain pay, which is considerably more than FO pay at Republic.