Do you have any time in a 310, 340, or 414? If you do and are comfortable in them you'll feel right at home (except for the geared motors).
The Continental GTSIO-520's always seem to be a topic of discussion. Treat them nicely and hopefully this company has good maintenance.
I've never been impressed with the climb rate but the Golden Eagle will eventually claw its way up to the low flight levels if you're going for a longer haul. It's also cool to see the turbos glowing through the cowling vents after you've set the mixture for cruise when you're in the upper teens or higher.
Oh yeah, the props have a huge diameter. They create quite a lot of drag when one is windmilling. Speaking of that (and this has been a topic of discussion around here) a lot of people advocate always landing a 421 with a little power because you don't want the air driving the props, which then drive the gearbox which is then connected to the crankshaft of the motor.