I have 75 hours in the 200. The plane is difficult to land, it is extremely heavy in pitch and this leads to some flat landings. The max demo x-wind is 13kts, compared to the II 17kts. It is terrible in a x-wind, the ailerons are tiny in comparison to the II and III etc. Some people say if you can land a Seneca consistently you can land anything. I think it flies nicely, very stable. It doesn't have a critical engine so during assymetric flight it handles well. Performance is ok, decent for a trainer, however it lacks a turbo and at altitude performance is rubbish.
I now fly the II and it is a much nicer aircraft, however the 200 was my first twin and I really enjoyed flying her.