Times have certainly changed since I flew for the "commuters". It's gone from hand flying BE99's, Shorts330's and Metro's with the most sophisticated equipment being a DME, to glass cockpit Regional jets that would make the B75/76 look like a DC8.
Back then, we operated under FAR135 regs instead of 121. We had no access to full fidelity flight simulators. We trained late at night in the airplane and could simulate only a few non-normals.
We flew 90+ hr months. These were all hand flown hours without the aid of an autopilot or flt director. After 5 years, I could thread the needle of any ILS without the LOC/GS needles so much as quivering. I doubt I could do the same today as my role is that of system and automation manager. Sure, we still have to be able to hand fly a single engine ILS in the sim during recurrent every 6 months, but in the real world, we normally fly each approach with the autopilot engaged...even if it were single engine. There were days at the commuter that we flew multiple hand flown ILS,NDB or VOR approaches to mins. These were done in all kinds of conditions as NE US flying could be real interesting especially in the winter.
While the aircraft have changed, the job of the "commuter" (Regional) pilot really hasn't over the years. These folks still fly max duty and flt days and do so safely in all types of conditions. I always equate the commuter or Regional pilot to a doctor of a M.A.S.H unit. They repeatedly deal with the worst conditions on a daily basis and not always with the best equipment. In essence, they become really good, really fast.
In my days at the commuters, those airlines were consider merely stepping stones to the big leagues. Nowadays, pay and equipment have far exceeded anything I thought they would. Many pilots there have more time and experience than I do. They fly 3-4 times what I do a year. Their proficiency far exceeds mine. Many could probably fly circles around me. Do I feel as safe flying a Regional vs the main line? Nowadays it's not even a concern of mine.