Which number?
Anyways- FAA medical guidance for label warnings: Do not Fly list
Label warnings. Airmen should not fly while using any medication, prescription or OTC, that carries a label precaution or warning that it may cause drowsiness or advises the user "be careful when driving a motor vehicle or operating machinery." This applies even if label states "until you know how the medication affects you" and even if the airman has used the medication before with no apparent adverse effect. Such medications can cause impairment even when the airman feels alert and unimpaired (see "unaware of impair" above).
Side effects for the active ingredients in Afrin:
Major Side Effects
If any of the following side effects occur while taking oxymetazoline nasal, check with your doctor immediately:
Blurred vision
fast, irregular, or pounding heartbeat
headache, dizziness, drowsiness, or lightheadedness
high blood pressure
increase in runny or stuffy nose
nervousness
trembling
trouble in sleeping
weakness
Notice that they both include drowsiness.
YMMV, but I've been told multiple times by OKC that it's a no go.