I assume you're talking about 121.
Several of my friends were able to land 121 jobs with 250/20 in 2007 at a couple carriers. Pinnacle/Mesaba(UND grad school, they LOVE UND!), and Piedmont in particular. After what, September this year, that will never ever happen again.
If you want perspective about 135. Where I work now, they switch back and forth between taking guys without 135 mins(1200TT, don't remember the rest at the moment

) and demanding it. We have such an issue with turnover, that they will take low time guys again I'm sure. Go figure right. I don't know anyone that would love flying 210s/Barons for much after the 6 month contract... The 250/20 guy will probably have no problem getting on somewhere like FLX during most times. I wouldn't recommend it. Might die with so little experience...

Where I HOPEFULLY will be working in a month will throw you in a beech 99(turbine) with my times of 2700 and 300 multi and previous 135 experience.
Are you looking for advice on where to get a bunch of total time in a short time OP? I'll give you my 2 cents. Aerial survey is your answer. Particularly a company that operates nationwide. You'll get lots of time AND experience. I'd recommend CFIing too to get your people skills developed. Though IMO, working retail in HS/college is much better for this. HR peeps love a candidate with many many many boxes checked though...
