It's a lot more complicated than just "do I go to a major over a regional?" Where will you be based? How much of a paycut (most CAs going from a regional to a major are gonna see one) will I take? How long will I be away from my family at a time? How stable is the major I'm going to?
All are questions (and some others) that need to be asked before making the jump. A few months ago, I wouldn't have even applied at NWA over upgrading here at PCL. Now that they're on the road to recovery contract wise, I might consider taking a job there (not that I'll get an offer, but the app is in anyway). I probably wouldn't make NWA my final career destination, but with PCL management playing head games and "hide the financial results" all the time, I see NWA as more stable than this particular regional. XJT's got a good thing if the gamble pays off in the end, so that's a regional I can see guys staying at for a long time. We've got guys that are more or less "stuck" here at PCL b/c they've either overstretched themselves financially to the point they can't afford the pay cut (albeit temporary) to go to a major or they just don't want to commute and live in MEM. Living in MEM and not commuting sorta limits your options.
My personal #1 goal is to get back on at SWA as a pilot instead of a ramper. In order to do that, I'll need the TPIC (coming next year), internal recs (working on that one as we speak), a 737 type rating (know where I'll probably get it that, but awaiting a "scouting report" on how the training is) and a lot of luck. Now, if while I'm working on that someone like CAL or DAL calls, I'd probably take that and shift my goals. DAL, Airtran and even jetBlue are all viable alternates b/c my goal is to move back to MCO. All are fairly easy commutes from MCO (ATL and FLL, even if Airtran and jetBlue don't open the rumored MCO bases). CAL is a little trickier, and I'd probably wind up moving to Dallas for that one and commute from there. I wouldn't mind FedEx, but I just don't want to live in MEM the rest of my life. United is a little shaky for me. They have no growth plans and no aircraft on order. To me, that's a prime candidate for a merger with someone else, so you run the risk of getting hired only to be stapled or going through an ugly merger with another airline.