mental math my friend.
using a 172 as an example with loose numbers (you will have yours from your flight plan)
If you know you are burning 10 gallons an hour, you establish your ground speed is 110 knots and the distance is say 15 miles
that is slighly less than 2 miles per minute at 15 miles is 8 minutes (est.) 8/60=4/30=2/15= about 1/7th of 10gal/hr about 1.2 gallons. ( i did this part as fast as I could type it I promise it was unedited)
If you check the actual math you get 8.1818 minutes (so the estimation was close) and you get 1.36 gallons (so again close)
Bottom line is do you have enough fuel. If the diversion ends up being larger than that (faster plane, longer distance, more fuel burn, etc...) you can work it out in a little more detail, however the E6B really isn't that hard to learn. Perhaps this will help.