There's a bloke here in the Oz army flying Super King Airs for 1st Avn Regt who lost both legs in an ultralight crash. I think he also flew Blackhawks after his prang. He had to jump over the physical hurdles as well as the inevitable institutional bias.
Folks like this have great role models, though .... Sir Douglas Bader lost both legs in an aerobatics prang in the 1930s. That didn't stop him claiming 29 air-air victories during WWII, though, and attempting multiple escape attempts after he was shot down and taken POW.