[FONT=Arial,Helvetica]Evidence regarding the existence and extent of fatigue in aviation has been gathered from several different sources and environments, including aviation operations, laboratory studies, high-fidelity simulations, and surveys. Studies have been consistent in showing that fatigue is an issue with complex, diverse causes and potentially critical consequences. Field studies specific to different aviation environments and using a range of measures (e.g., performance, physiology, and behavior) have revealed a number of factors related to fatigue. For example, in long-haul operations, the non-24-hr duty/rest cycles, the circadian desynchronization associated with transmeridien flights, and the sleep loss accompanying nighttime flying are all associated with fatigue (1). For short-haul operations, long duty days, sleep loss as a result of short nighttime layovers, and shortened sleep episodes due to progressively earlier report times across trips serve to create flight crew fatigue (2). In overnight cargo crews, even regular nighttime flying often results in incomplete circadian adaptation. Additionally, duty periods ending in the morning hours lead to sleep loss due to an increasing signal for wakefulness from the biological clock during this time. The problem is compounded by daytime layovers that can sometimes be too short for an adequate sleep opportunity (3). [/FONT]