Oh Oh Ohhhhh GLP-1!!!

skypilot6

Well-Known Member
Disclaimer: The following contains my personal experience and options with taking GLP-1 Medications for Weight Loss. ALWAYS consult your doctor before making major changes to your health. This post is in no way medical advice or to be a guide in talking GLP-1 medications.

One year ago I began taking Mounjaro for weight loss. It has helped me lose 75 pounds in a year.

Before, 250ish pounds:
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After, 175 Pounds:
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GLP-1 Medications were originally developed to help Diabetes patients to help control their blood sugar. GLP-1 is a naturally occurring hormone that helps regulate blood sugar levels. GLP-1 agonists mimic this hormone and, Stimulate the pancreas to produce more insulin, Slow down the digestion of food, and Reduce appetite.
The most common GLP-1 medications are Semaglutide (Ozempic, Wegovy), and Tirzepatide (Mounjaro, Zepbound). The marketing name relates to what the drug is approved and prescribed for, however the medications themselves are the same. I was prescribed Mounjaro which is the Diabetes medication, whereas Zepbound is the same drug prescribed for Weight Loss. My health insurance would NOT approve Zepbound without jumping through a lot of hoops, Mounjaro on the other hand was approved no questions asked. The medications can also be obtained through third party services for a monthly fee or subscription. The medications are a once weekly injection, usually in the Abdomen or Thigh. The medication is preloaded in a Pen which is easy to use and takes about 3-4 seconds to administer once a week.

The FAA requires a 2 week observation period when starting the medication. I started it right before a vacation last year for the the ONLY side effect I experienced was a bit of mild nausea which is expected when starting out, after that its been fairly easy. The medication for me pretty much turned off my appetite, some people will say it turns off the "food noise" which is proably the best way to put it. Ive been overweight the majority of my life, the medication gave me control to eat what I need to eat and not always feel hungry. I have always struggled with my weight, gone up and down several times, and this is what has worked the best by far.

The medication in conjunction with a healthy diet are key. You will eat less, plain and simple. A normal meal will feel like the third plate at thanksgiving almost every time. So eating more whole foods and getting enough protein is very important. The one area where I have been lacking is in fitness, and unfortunately I can feel it, weight training is a must as the medication will affect muscle mass, I've started to work out more with weights and less cardio and I feel much better because of that.

The FAA has a Weight Loss Management form which you can find with a simple google search, you will need your health care provider to fill it out. It does ask for a current A1C reading so you'll need blood work for that. It's also a good idea to get blood work before beginning GLP-1s to make sure your not pre diabetic. I brought the completed form and a letter from my doctor to my medical last week and got a fresh First Class medical on the spot. Also I have been taking lisinopril for high blood pressure for about the last decade, with my weight loss I am no longer on lisinopril and have been seeing my BP around 117/70 for the last few months.

My heaviest weight was 277 pounds, size 40-42 pants, XL-XXL shirts. At my Medical last week 175, size 32, Medium shirts. I feel like a completely new person. I sleep better, I move better, I have a lot more confidence in myself it really has been a life changing experience. Taking the medications is NOT for everyone however. I know several friends and family that have not had a good experience with it, as everyone is different what worked for me, won't necessarily work for someone else.

As with any drug there are risks, talk to your doctor of course, for me the benefits far outweighed the risks, I've been very happy with the drugs and the results.

Any questions, please ask.
 
I’m right behind you.

End of “Week 1” because my digestive health doctor, I was occasionally having problems swallowing food and had acid reflux at night quite literally said “It’s all BMI, you need to lost 20% of your body weight”.

My general practitioner, when I said I’d cut back booze and work out more, laughed and said at my age and lifestyle, I was better off getting it down to non-obese BMI and then maintaining lifestyle choices to maintain that.

Plus, every photo I’ve taken post-COVID, man I look like “Fat Thor”. Must be the lighting, or the angle, or because everyone else in the frame is fit. Nah, I’m just 220 lbs and I’m only 5’9.

Soooo, we’ll see how it goes. Zero side effects so far, I feel full a lot quicker and after a glass of wine, I’m largely bored with having another.

The cool part is, is that I can have a margarita without thinking, ooh, lemme order another one and hot damn, nachos sound good! A third once the nachos arrive? Sure, I don’t mind if I do!

Zero food cravings, alcohol doesn’t set off my hunger at all. Hell, I don’t obsess over either and it’s only been a week. I’ve been cutting back on booze and snacks and stopped relying on brisk layover walks to substitute for exercise (I do both now) and that was almost 10lbs there, down another 3 after heavier exercise and GLP therapy started. I’m down to 207 now.

Special shout out to @skypilot6 because I was tremendously reluctant, heard all of the horror stories and he let me ask all the weird questions while answering with care and patience with me. If it wasn’t for him, I wouldn’t have had the confidence to give semaglutides, wait for it… A SHOT! :). Thanks for serving as my ‘big brother’ on this journey.
 
This thread was aimed to help spread info about GLP-1 medications. A few months ago after a night on the Saturday night zoom a few JC’ers reached out asking questions about it. I hate using the world miracle but this really has been a miracle so far.

I lost 75 pounds, my buddy lost 80, another 110, my wife is currently down 35, my mom is down 20. All of us struggled with our weight our entire lives. We’ve all done the diets, the shakes, the supplements, the workouts and all have ended up back where we started. Which may happen again but nothing has worked as well as this has for any of us so far.

And as far as the FAA is concerned, as long as you’re not pre diabetic or diabetic before you start it’s really just a form to fill out with a current A1C reading.
 
I'm gonna be on board soon too. After talking to you a couple months ago I scheduled an appointment with my doc to get the conversation started. That's scheduled for early November. Tonight at Dinner with Doug it was obvious. I was on my third drink and an extra bratwurst on top of the tostada I already ate... Meanwhile Doug barely ate half his sandwich and just 1 beer but said how satisfied he was.
 
I'm gonna be on board soon too. After talking to you a couple months ago I scheduled an appointment with my doc to get the conversation started. That's scheduled for early November. Tonight at Dinner with Doug it was obvious. I was on my third drink and an extra bratwurst on top of the tostada I already ate... Meanwhile Doug barely ate half his sandwich and just 1 beer but said how satisfied he was.

And that sandwich was Top Five sandwiches too, so good, so I hated eating only about half of it. And the beer was delicious but my brain was happy with about 3/4’s of it over the span of what, four hours?

A month ago I would have eaten the whole thing and probably be drunk in your backyard after drinking all day, wondering who will deliver at midnight.
 
so it just makes you less hungry?
sounds like you could channel rj pilot brainwaves and get the same result. zen is $18 in per diem and student loan debt
/s

happy you are healthier but hope you can put on muscle to make up for it. everyone I know thats been on the glp train looks gaunt but flappy from how fast they lost the weight with little exercise
 
Congrats! One of my crashpad-mates did it a couple of years ago and he had huge success, now he's on a maintenance dose.

I've pretty much done everything too, but somehow with the lifestyle of changing circadian sleep cycles, airport food, layover food, and career uncertainty I bounce my weight around all over the place like a bad rollercoaster. Food has always been my vice and I'm getting too old to run my engine hot.

So, I'm done... I had the initial convo with my GP and after my yearly physical we are gonna probably startup a program. If I can get back to my 2016ish weight I'll be very happy.

I still haven't gained all of it back after my last big loss, but I've been trending upward for like a year or so (+20) and it's time to reverse the course.
 
so it just makes you less hungry?
sounds like you could channel rj pilot brainwaves and get the same result. zen is $18 in per diem and student loan debt
/s

happy you are healthier but hope you can put on muscle to make up for it. everyone I know thats been on the glp train looks gaunt but flappy from how fast they lost the weight with little exercise

I really don't know. It seems like it turns off the addictive nature of foods and alcohol. Like I love steak, but I'm satisfied after about half of it. I love (!!) wine, but I'll nurse a glass most of the night and I don't feel like I've cheated myself nor does it take any willpower.

It's like drinking a can of coke. It's delicious but halfway through it, you're just done and forget you have it open and then it goes flat.

I still obsess over food because I love to cook, but I'm satisfied quicker.
 
For those not ready to try the pharmaceutical intervention just yet, I’m down 40 lbs since this time last year, just using the free version of the my Fitness Pal app and walking an hour a day.

Ok, I get the whole anti-better living through chemistry thing.

Here's the thing about that. What you are doing does work. Walking, food tracking... apps... weight watchers, my fitness pal - whatever. The whole world has literally crowdsourced every food into those apps. I've done it - 3+ times. And each time I always likened it to "joining a cult" or when people used to ask me about my weight loss "journey" I'll just say that I have a touch of the ebola. (more on that in a min)

For me... it's my relationship with food. Plain and simple. Grew up somewhat poor, 80's latchkey kid, divorced parents, going all in and moving 2000 miles away from any support system for college.... the whole nine yards. I probably obsess over food, I probably "hoard" food. I didn't know where my next meal was coming from (a lot) and with the divorce stuff I had to take care of my own food needs a lot between 15 to adulthood. It wasn't healthy and food & emotion got all intertwined.

I learned a lot about "clinically" what is going on in my head when working with a nutritionist for my kids and I've been trying to break that particular generational trauma. Previous lifestyle changes were all about trying to change my relationship with food... it never stuck.

Just like music and sexual preferences... I was programmed between 12-14 to like what I like. (pop psych news flash for anyone reading this... your music, fetishes, partner preferences - imprinted during adolescence. Guns and Roses, Def Leppard, and AC/DC isn't awesome because it's universally perfect music, it lust lives in your lizard brain. How I deal with food is all intertwined with what happened to my adolescent self.

Back to the ebola bit. Weight loss is hard, talking about diet give you that same dopamine hit as actually doing something about it. The first rule of Fight Club, at least for me, has always applied to diet/lifestyle changes. I need a small support group and then I don't talk about it at all. Because as soon as you start talking about it, you cheat, you fail...

All of this tl:dr to say... it's all about that food noise for me. Look around the world, there is food "porn" everywhere. You don't realize it till you start looking at it. And paying attention.

I'm glad that you are able to control your weight through lifestyle changes. I've gotta try something different this time around. I just haven't been able to jumpstart the changes I need to make because it's just been too damn hard with everything else around me.

Anyhoo... my GP had a cancellation, I'm going in tomorrow to have the initial conversation, I have the first couple of weeks of November off, that's a great time to start of I can get the ball rolling.
 
Oh I'm not anti anything, and not shaming you. Just saying there are probably steps to try before it reaches that point. But once you've exhausted non medical options, of course go for it! Best of luck!
 
I really don't know. It seems like it turns off the addictive nature of foods and alcohol. Like I love steak, but I'm satisfied after about half of it. I love (!!) wine, but I'll nurse a glass most of the night and I don't feel like I've cheated myself nor does it take any willpower.

It's like drinking a can of coke. It's delicious but halfway through it, you're just done and forget you have it open and then it goes flat.

I still obsess over food because I love to cook, but I'm satisfied quicker.

I’m so jealous. I tried a little dose for a couple weeks and constantly felt like I was going to puke.. so back to willpower and exercise. 😔
 
I’m so jealous. I tried a little dose for a couple weeks and constantly felt like I was going to puke.. so back to willpower and exercise. 😔
A little over a month-in and while I haven’t titrated up to a higher dosage, zero symptoms.

Cutting out about 95% of the cravings for alcohol when it’s social time has brought me tremendous clarity.
 
Oh I'm not anti anything, and not shaming you. Just saying there are probably steps to try before it reaches that point. But once you've exhausted non medical options, of course go for it! Best of luck!

Thanks! It’s tough (mentally) when you realize that pure "willpower" isn't gonna cut it... or to use a meme/tweet to explain it better:

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Anyhoo, I still have to give AMAS a call to go over the paperwork and triple check everything, but my regular doc said I'm a great candidate and cleared me to begin. (I already blocked the time in my schedule for the observation period because of my vacation) I'm fascinated to see what it's going to feel like to not have that constant food noise in the background.
 
I’m so jealous. I tried a little dose for a couple weeks and constantly felt like I was going to puke.. so back to willpower and exercise. 😔
Which one were you trying? My mom originally was on semaglutide and was having issues, especially when she ate certain foods. She switched to Trizepatide and is doing much better. If it’s still something you’d like to do it might be worth trying a different route.
 
Thanks! It’s tough (mentally) when you realize that pure "willpower" isn't gonna cut it... or to use a meme/tweet to explain it better:

View attachment 86098

Anyhoo, I still have to give AMAS a call to go over the paperwork and triple check everything, but my regular doc said I'm a great candidate and cleared me to begin. (I already blocked the time in my schedule for the observation period because of my vacation) I'm fascinated to see what it's going to feel like to not have that constant food noise in the background.

I’m about to go up a level. One month in and zero side effects besides weight loss and zero food/booze noise. I think I nursed half a beer during three hours on the Zoom happy hour this weekend.
 
Hi all (been awhile.) it's been great for me as well, I started at about 270 lbs about 18 months ago, and am 192 as of this morning, on Zepbound. I hit 188 a few weeks ago, but I've had to go down in dose (I was on 12.5mg, i went down to 7) due to just having too much nausea unfortunately. It was tolerable when I wasn't working, but after I called off mid-trip for it and then had to sick out again a week later, I decided job > high dose for now. Hopefully I can at least maintain on 7, and i'll try to titrate back up to 10mg once things are a bit calmer in life, I was fine on 10 before, I just wanted to give body a bit of a break and make sure I'm not dealing with ANY side effects for awhile while I learn the new airplane. I'll probably have to stay no higher than 10 and just really hit the workouts and diet to get that last 40 lbs off.
 
Hi all (been awhile.) it's been great for me as well, I started at about 270 lbs about 18 months ago, and am 192 as of this morning, on Zepbound. I hit 188 a few weeks ago, but I've had to go down in dose (I was on 12.5mg, i went down to 7) due to just having too much nausea unfortunately. It was tolerable when I wasn't working, but after I called off mid-trip for it and then had to sick out again a week later, I decided job > high dose for now. Hopefully I can at least maintain on 7, and i'll try to titrate back up to 10mg once things are a bit calmer in life, I was fine on 10 before, I just wanted to give body a bit of a break and make sure I'm not dealing with ANY side effects for awhile while I learn the new airplane. I'll probably have to stay no higher than 10 and just really hit the workouts and diet to get that last 40 lbs off.

At which level did you start getting side effects? I just went up to 5mg and it’s been super chill so far.
 
Hi all (been awhile.) it's been great for me as well, I started at about 270 lbs about 18 months ago, and am 192 as of this morning, on Zepbound. I hit 188 a few weeks ago, but I've had to go down in dose (I was on 12.5mg, i went down to 7) due to just having too much nausea unfortunately. It was tolerable when I wasn't working, but after I called off mid-trip for it and then had to sick out again a week later, I decided job > high dose for now. Hopefully I can at least maintain on 7, and i'll try to titrate back up to 10mg once things are a bit calmer in life, I was fine on 10 before, I just wanted to give body a bit of a break and make sure I'm not dealing with ANY side effects for awhile while I learn the new airplane. I'll probably have to stay no higher than 10 and just really hit the workouts and diet to get that last 40 lbs off.

Can you talk a bit about how it affected your relationship with food? Was it the nausea that kept you away from eating... making it easier to change your lifestyle/eating plan etc.? I'm just trying to figure out what I am in for vs. the whole placebo effect and the normal effects of writing down everything that goes into my mouth. Also, has changing the dose caused you to go right back to earlier patterns - or does some of it stick?
 
At which level did you start getting side effects? I just went up to 5mg and it’s been super chill so far.
Ohh man it's tough to say because I started on Wegovy, and got them a little bit on 1mg and then at 1.7mg it was getting pretty significantly bad. After 9 months-ish? I talked to the Dr and said my friend is on Zepbound and has had no side effects, can we try switching - and they switched me directly to 12.5mg (the dosages don't exactly correlate but they have some idea, I guess.). It was an improvement at first but eventually did feel like it was getting worse, so they switched me to 10mg. 10mg pretty much killed all the side effects for me, aside from occasional acid reflux but I get that anyway - however, I stopped losing weight on 10mg and just started maintaining. So I went back up to 12.5mg accepting that I might have some side effects occasionally but wanted to keep losing weight, and resumed losing a lb a week. And that was all fine and well when I was out on medical and not flying, but when I returned to training, the nausea was starting to get a bit annoying, but still, you're just in a simulator so waking up a little bit nauseous, • it, we ball, it'll probably go away at some point in the day... However, some bad food poisoning led to getting hospitalized during training for colitis (totally unrelated, but the GI tract was not happy for a bit and I stopped all dosing for about 15 days until they cleared me to start back up again.) But that was sick call #1.
Then I had a life event preplanned trip at what would have been the end of my scheduled training, but with various delays training ran into it... Sick call #2 because the CPO refused to life event drop saying ohhhh you're good on attendance we'll just drop it with sick time, we don't want to recode it for you, sorry. (This is •, but c'est la vie. Sorry I planned something while I was out for 2 years not knowing exactly when I'd suddenly get my medical back and have 3 business days to send it to the company...)
Sick call #3 I was out on an easy OE 2 day, had a marriott hotel cheeseburger that night (not the best choice, too rich.. but... they didn't have the best menu), then spent most of the night awake/vomiting with nausea, finally got a few hours of sleep, woke up and vomited again... had to call out mid trip and get deadheaded. I'm thinking, alright, that can't happen again, I need to be reaaaally careful with what I eat on trips, and maybe it's time to think about reducing dose.
Eager to complete my OE and get released to my schedule, 8 days later I see a great Geneva trip with an LCA open in 2 days and call them to get that trip.... and... the morning of, feel really nauseous, vomit 3 times, and feel really dumb calling out sick for the trip I ASKED the OE desk to give me. Sick call #4 and now I'm actually starting to get concerned because the FAA says you can't fly sick, but we do have an attendance and reliability policy and... yeah. I don't want to run onto the wrong side of it. So I called my doctor and said I need an immediate reduction to 7.5, and they said are you sure you don't want to drop back to 10 and I said no, I just can't take any chances with it right now, I can't be getting sick from this medicine. Let's go down 2 levels so I'm /sure/ I'll be good, and then in 8-12 weeks if all is well, we can titrate me back up to 10 carefully. I will probably avoid 12.5mg entirely, it seems like I just can't handle it.
Sorry for the long post but yeah, in my situation I think it makes sense why I dramatically titrated down for now. I just did the second shot of 7.5mg last night, and so far all was still quite good today.
 
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