I've been in the two-homes situation twice in my life, and without being a wet blanket, here are some moisture tips. Growing up, it was a migration: day and a half each way. Since my dad was a college professor when they worked a nine-month year, we just stayed. We eventually duplicated everything we didn't want to schlep back and forth.
My second wife came with a cabin in the Rockies near Denver - spoils from her first marriage. She did the single-mom drive from SoCal; kids in the back seat sleeping, some 19 hours drive, but she could just pull over and take a nap. We got together and then lived five and a half hours' drive. Two-day weekends were hell. Get off work, drive (with the last hour or so being very windy mountain roads). Fall into bed, spend Saturday on chores (see below), sleep in Sunday and reverse the process (including a time zone working against you this direction). We learned, and did 3-day weekends, more often week-and-two-weekends or a real vacation.
We still share that cabin (at different times), though not the marriage. Two thousand miles makes it a migration of 3-4 days. I now plan a break for a museum or something else fun. There's only one shortest-route, but I do vary it. We have a list of handy-men for emergencies.
Chores: A lengthy list of little maintainances that often include more systems each with their own needs and urgencies: well & pump, dirt roads, drainage, 'mountain construction' to prop back up, and more. There's always wood to gather, chop & split - can't do without the fireplace. Be careful about your list of projects - you're there to relax, right? Never more than one big one per year! Cluster them, don't bite off more than your energy will handle. Bring friends and do a 'barn-raising.' Don't do too many back-to-back!!!!! Develop a marital protocol for additions and interruptions to the honey-do list. Duplicate stuff - I'm a tool guy, so Harbor Freight is my friend. If I needed precision and quality, I'd bring a tool with me, but for most stuff, yard-sale, older versions of things I've replaced or bargains will work just fine. Ditto kitchen. Spring opening and fall closing always include one thing that breaks, leaks or won't come back to life.
Do things that are fun, make friends in the neighborhood. Nothing like lying on the roof and seeing the stars - all of them - without the metropolitan light pollution at home. Second-home version of Date Night. Plan to enjoy it.
Happy house hunting!