We always check cabin pressure passing 10K MSL......and since my hypoxia incident a while back, I regularly scan the cabin press gauge. There is an alarm that will go off for us when cabin pressure gets really really low (as in DCS risk land), but generally, it is very insidious with no built in warning. When I got it for reals, it was the result of switching ECS to a manual mode (checklist item for the unrelated problem I had been having), and basically the ECS is real touchy and loves to surge in that setting. Had the pressure dump from 8k (normal) to 27k in seconds, and cycle several times in that manner. Started losing depth perception, and motor skills, and didn't even have the good sense to pull the emergency O2. I was pretty wrapped up in rapidly descending, while still clinging to the idea that I could fix the problem and continue with the flight. It really took a number of minutes (after getting below 10K) until I realized what had happened. It is not only a scary phenomenon, but one that also robs you of the good sense that is required to survive. We have lost dozens of guys to similar circumstances in my community, so I consider myself lucky, and hopefully more prepared to deal with it next time. At that point in my career, I had done either the decompression chamber, or the ROBT at least 3-4 times. It really made no difference, aside from an after the fact feeling that I had seen that before. You are just too spaced out in the moment to really think clearly enough to say to yourself "hey, I am hypoxic" most of the time. Just my .02