I've never flown a G1000 equipped aircraft, but I can't imagine it gets any more straightforward than the Avidyne. A retarded pet rock could operate it, which is probably why I like it so much. The only thing I'm wary of is the fact that the Avidyne doesn't have a reversionary display mode; if one screen craps out, you're SOL.
I have had a few problems with the Avidyne though (in a Cirrus). It may or may not be the Avidyne's fault, but we've had the MFD sent out for repair due to the display flickering, the autopilot stopped talking to the PFD yesterday, the MFD loses communication with the TAWS, Skywatch and heading data on a regular basis (I think this one is cause by a faulty transponder that is causing electrical interference; we'll know for sure when the new one comes in).
Avidyne really crapped the bed when it came time to do a WAAS upgrade. Six weeks of downtime waiting for them to do the software upgrade on the PFD. After working our way up the chain of command at the company through phone calls, the company president informed us that he had no idea that delays were that lengthy. On the other hand, every avionics tech we've ever talked to has said that Avidyne takes forever in getting their boxes repaired and returned to service.