The Airbus philosophy is very different. A330 pilots usually like it very much, in direct law it is a fantastically enjoyable airplane, it's powerful and quiet, A320 pilots have more mixed feelings, the A340 feels like a big 330, pretty neutral and not that responsive. Don't know any A380 pilot yet.
You get used to the sidestick in a matter of minutes, the lack of feedback is disconcerting at first, but you don't notice it after a little while. And the space freed by the absence of yoke is nice.
See, Airbus philosophy closely reflects pilot training in Europe : a lot of emphasis on theory, you get hired with 250hrs but with a huge technical knowledge. Airbus made the planes very user-friendly but as soon as you start scratching a little bit things get very complex. It wasn't so much the case with Boeing but it is becoming that way too.
I like older Boeings better though. The 72 conveys a very strong image for me, so's the DC10, wish I could've flown these birds...