Related; can also solve the urban transport dilemmas mentioned in this thread:
Thread 'France bans short-haul flights'
France bans short-haul flights
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However the problem with drones is that it multiplies the scale of "mechanical deterioration" and risk of malfunction. It's more efficient to track the "health" of a single, bigger machine.
Perhaps airplanes will simply evolve but I don't think the demand for airplane travel is going to change for another generation or two.
The need for human operators is ethical but also practical. However it might start to be more customer service oriented than a technically-skilled work.
I'd prefer to take an air taxi if a licensed and experienced human were operating it and I wouldn't want to take the ride further than to a neighboring county.
Regional short haul flights might disappear though. I wonder how that will affect the way thay pilots and dispatchers (and other op support that I don't know about since I am an ignoramus about the full scope of aviation ops) get experience for mainline work (or whatever else is out there).
The relationship with the variously sized airlines might also change. The quantity of airplane pilots might shift or decrease. I don't see why a regional airline would exist, especially if autonomous drones can deliver cargo, and interface with railway systems for that, and urban corners can integrate air taxi (and use rideshare services for that too).
[The image is from a DOT and FAA communication on conceptualization how to regulate and manage urban airspace]
It was on my reading list but I didn't expect that I'd be referring to it again so soon.