I don't do it all the time, but I've commuted to work in an RV-6 a handful of times.
For me the biggest logistical item is the ground time. How long are you going to be driving versus what can you save by flying?
I was driving 2.5 hours, roughly. I was flying about 45 minutes. However, I was driving 20 minutes to the plane, then another 10 or so minutes getting the plane ready to fly, then flying the leg, getting the plane secured (and paying the ramp fees) and driving to the "office." Which meant parking in a crew parking lot, getting on the bus, and doing the normal joe blow routine and by the time it was all said and done, it was just easier to drive in.
I still do it occasionally, but only if it's going to be stress free - ground school, recurrent, a sim, something like that.