I doubt it would make any difference. I'm taking Riddle classes online, and the diplomas look exactly the same as the residential diplomas. As far as transcripts, it probably depends on the college. When I interviewed for SWA, they wanted a copy of your diploma if you went to college, and they wanted a copy of your HS diploma. I had my transcripts from HS since I was in the middle of getting accepted to ERAU, but I wasn't sure where my actual diploma was. SWA wouldn't take the transcript, they wanted the diploma.
Bottom line is, you did the work, you passed the class, and the college is accredited. If an airline turns me down b/c they feel I didn't work as hard in school as some guy who went to a residental campus, I'd rather not work there. I think it's actuallly HARDER to do classes on-line. At least when I was on campus at MSU, there were teachers and other students to help me out.